Up regulation of skeletal muscle IL‐6 mRNA in response to hyperthermia
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چکیده
منابع مشابه
The Response of Skeletal Muscle-Expressed Neurotrophins to Acute Resistance Exercise in Male Wistar Rats
Background. BDNF and NT-4/5 have been proposed to be involved in the coordinated adaptations of the neuromuscular system to the elevated level of activity, but an activity-dependent expression of neurotrophins in skeletal muscle is not well established. Objectives. We, therefore, investigated the effect of one session of resistance exercise on mRNA expression of some neurotrophins in Slow and ...
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TRADITIONALLY, THE DRASTIC increase in circulating IL-6 and other cytokines seen during exercise was thought to originate from mononuclear cells associated with the general inflammatory response. Activation of the IKK/NFB pathway associated with inflammation would lead to the production of IL-6 and other cytokines (1). However, more recent data have shown that IL-6 expression remains unchanged ...
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متن کاملA rapid up-regulation in UCP3 transcriptional activity in response to moderate intensity exercise in rat skeletal muscle.
Uncoupling protein 3 (UPC3) is a candidate protein transporter that uncouples oxidative phosphorylation of mitochondrial respiration in skeletal muscle. A number of studies on UCP3 functions under various physiological conditions have suggested that the function of UCP3 is not limited only to regulation of whole-body energy metabolism but is also involved in regulation of substrate (lipids and ...
متن کاملThe Impact of Hyperthermia on Receptor-Mediated Interleukin-6 Regulation in Mouse Skeletal Muscle
In inflammatory cells, hyperthermia inhibits lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) gene expression and protein secretion. Since hyperthermia alone stimulates IL-6 in skeletal muscle, we hypothesized that it would amplify responses to other receptor-mediated stimuli. IL-6 regulation was tested in C2C12 myotubes and in soleus during treatment with epinephrine (EPI) or LPS. In EPI-...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.1046.11